Transcription factor FOXM1 deficiency increases the development of chronic kidney disease after acute injury: insight.jci.org/articles/view/… ASCI member Benjamin D. Humphreys and colleagues Ben Humphreys WUSM Department of Medicine WU in STL Nephrology elucidate the mechanism in their new paper.

Controlling tumors with natural killer cells ASCI member Todd A. Fehniger Fehniger Lab and colleagues Test Account discover an induced NK cell subset with enhanced tumor control: jci.org/articles/view/…

Research from ASCI member Samuel C. Dudley Jr. and team UMN Medical School shows that macrophages orchestrate increased risk of atrial fibrillation in a type 2 diabetes mouse model: insight.jci.org/articles/view/…

ASCI member Qais Al-Awqati Columbia Medicine unfolds a fascinating history of cholera, revealing chloride channels as an unexpected link to other diseases in this JCI 100th-anniversary celebration viewpoint: jci.org/articles/view/…

A surprising exchange—neutrophils observed inserting elastase-containing granules into liver cells from an alcohol-associated hepatitis sample. The exchange reduced cell proliferation without toxicity. Research from ASCI member Michael H. Nathanson Yale School of Medicine: jci.org/articles/view/…

An investigational drug alleviates lung fibrosis in a mouse lung transplant model: jci.org/articles/view/… ASCI member Vibha N. Lama Vibha Lama's Michigan Medicine group report on fibrogenic transformation & MNK inhibition as a potential treatment in chronic lung allograft dysfunction

An enteric start to HLA-B27-associated autoimmune disease? insight.jci.org/articles/view/… Work from ASCI member Wayne M. Yokoyama's team suggests early antigen exposure in gut leads to pathogenic CD8+ T cell development in axial spondyloarthritis and acute anterior uveitis. Test Account

Familial gene variants lead researchers to autoimmune disease mechanism in IgG4-related disease: jci.org/articles/view/… Latest study from ASCI member Jörg J. Goronzy and team @Mayoclinic

Murine lupus protection and regulation of TLR7: insight.jci.org/admin/posts/220 In this video, authors from ASCI member Mark Shlomchik's lab University of Pittsburgh describe the mechanism of how NOX2 deficiency exacerbates lupus via TLR7 signaling. Article: insight.jci.org/articles/view/…

Patient-specific cell model highlights potential benefits and differences for gene-therapy in rare blinding disease: insight.jci.org/articles/view/…. Study from the lab of ASCI member Stephen H. Tsang Columbia University in JCI insight

An evolutionary genetics-phenome-transcriptome approach shows how a human-specific gene underlies colorectal cancer risk: insight.jci.org/articles/view/… Work led by ASCI members Ajit Varki and Pradipta Ghosh UC San Diego

Why does NOX2 deficiency exacerbate systemic lupus erythematosus in mice and humans? insight.jci.org/articles/view/… Work from ASCI member Mark Shlomchik University of Pittsburgh in JCI insight shows how NOX2 in both macrophages and B cells is protective.

The cancer-associated secretory phenotype: A new frontier in targeted therapeutics: jci.org/articles/view/… ASCI member Jonathan M. Kurie and team highlight a therapeutic strategy for targeting cancer in this Viewpoint. MD Anderson Cancer Center Tulane Medicine

Untangling inflammation from fibrosis in metabolic dysfunction-associated fatty liver disease: jci.org/articles/view/… ASCI member Tamer Sallam's team David Geffen School of Medicine at UCLA deleted hepatic lipopolysaccharide binding protein and reduced inflammation but not fibrosis in Western diet mice.

Zebrafish model provides insight into craniofacial birth defects associated with proteasome mutations: insight.jci.org/articles/view/… Check out new work from ASCI member Wolfram Goessling's group Harvard Medical School in JCI insight

Is it time to rethink the relationship between adipose inflammation and insulin resistance? jci.org/articles/view/… A JCI 100th Anniversary Viewpoint from ASCI member Evan D. Rosen BIDMC!

How do sex hormones support metabolism? jci.org/articles/view/… ASCI member Franck Mauvais-Jarvis Tulane Medicine describes how estrogens and testosterone play important roles in female and male metabolic homeostasis in JCI's review series on Sex Differences in Medicine.

Kicking off the 2024-2025 ASCI Scientific Sessions: Rohit Loomba, MD, MHSc Rohit Loomba "Advances in Non-Invasive Assessment and Management of MASLD" Sept. 17, 1-2pm ET Moderator: Dr. Christopher Williams Vanderbilt School of Medicine Free & open to all. Register: buff.ly/3AV60Fo

Go, Flight! Exciting editorial from JCI insight's new Editor in Chief Oliver discussing goals and new initiatives of the University of Pittsburgh-based Editorial Board! buff.ly/3zeM28b PittDeptofMed @paccsm

Get the fat on endometrial cancer: buff.ly/4g7xJmm Obesity is a risk factor for endometrial cancer but ASCI member Paul Cohen and colleagues Rockefeller University show it may be protective in people who have the disease and are undergoing immune therapy.