Parkin is an epigenetically silenced activator of innate immunity and tumor suppressor, inhibiting intrinsic tumor traits of metabolism and cell invasion, while reinvigorating CD8 T cell functions in the microenvironment Journal of Clinical Investigation jci.org/articles/view/…

PERK inhibitor perks interest in type 1 diabetes: jci.org/articles/view/… Charanya [सरण्य], Raghu Mirmira, and team Center for Diabetes and Metabolic Diseases show inhibition of the eukaryotic Initiation Factor-2-alpha Kinase PERK decreases the risk of autoimmune diabetes in mice.

Brown fat cells muscle-up with myostatin. New research shows myostatin produced in brown adipose tissue regulates thermogenesis.

What causes primary immunodeficiency associated with thrombocytopenia? This issue’s cover image features abnormal lymphocyte spreading from an infant with a RAP1B gene variant. Check out Benavides-Nieto et al. Inserm: jci.org/articles/view/…

A new viewpoint from Rosen and Kajimura Journal of Clinical Investigation BIDMC "For now, however, we believe that the community should approach the notion that inflammation is the driver of #insulin resistance in humans as a hypothesis, rather than a proven fact" jci.org/articles/view/…?

Here the authors identify GLP-1 receptors in the mouse lateral septum as critical for the anorectic effects of liraglutide #weightloss Journal of Clinical Investigation jci.org/articles/view/…

JCI - Cancer therapy–related salivary dysfunction- jci.org/articles/view/…

The cancer-associated secretory phenotype: A new frontier in targeted therapeutics. Jonathan M. Kurie and team highlight a therapeutic strategy for targeting cancer in this Viewpoint. MD Anderson Cancer Center Tulane Medicine

Paper alert 🤩 stoked about publishing our story on transcriptional heterogeneity of breast cancer, profiling primary tumors and their matched metastases at single-cell resolution. out today in Journal of Clinical Investigation jci.org/articles/view/…. check out the 🧵of the pre-print 👇 1/n

Hamburg news II: New perspectives in nephrology; first Adeno-associated virus (AAV)-based gene therapy targeting glomerular endothelial cells to treat inflammatory kidney disease. @HCKH, Universität Hamburg, UKE Hamburg Journal of Clinical Investigation ASCI Nationale Akademie der Wissenschaften Leopoldina jci.org/articles/view/…

Untangling inflammation from fibrosis in metabolic dysfunction-associated fatty liver disease. Jihane Benhammou Tien Dong MD, PhD & team David Geffen School of Medicine at UCLA delete hepatic lipopolysaccharide binding protein and reduce inflammation but not fibrosis in Western diet mice.

Check out latest Journal of Clinical Investigation paper where Wistar researchers in the Altieri lab uncover Parkin's role in cancer and T cell activation: jci.org/articles/view/…

What can a single cell tell us about metastatic breast cancer? Juliane Winkler and team UC San Francisco profiled single cells from breast cancer tumors with metastases revealing gene signatures linked with metastatic potential and patient outcomes.

Breaking the link between #obesity and #atrialFibrillation with a new cellular target Journal of Clinical Investigation medicalxpress.com/news/2024-09-l…

Our group HITh collaborated on this amazing study in #JCI and are on the cover! - Somatic RAP1B gain-of-function variant underlies isolated thrombocytopenia and immunodeficiency Journal of Clinical Investigation jci.org/articles/view/…

Is it time to rethink the relationship between adipose inflammation and insulin resistance? Evan D. Rosen and Shingo Kajimura Lab contribute a JCI 100th Anniversary Viewpoint! BIDMC

Why do some people get Lyme arthritis despite receiving adequate antibiotic treatment? Researchers examined the joint fluid of teens with antibiotic-refractory Lyme arthritis and found a specific immune cell. Check out Dirks et al. Universität Würzburg #UniWürzburg

Leveling up in the microbiome game with guild-based strategies! Liping Zhao and authors discuss a guild-based approach for mitigating information loss and distortion issues in microbiome analysis in their Viewpoint.

In 1976,a cluster of children near Lyme Connecticut alerted researchers to Lyme arthritis: jci.org/articles/view/… Allen Steere comments on Dirks et al. jci.org/articles/view/… in wider recognition & greater understanding of post-infectious, antibiotic-refractory Lyme arthritis