Great lecture. Kind and generous to share. UCSF Health is lucky to have such a thought leader.

Initially I laughed but this changed quickly to sadness regarding my profession

I just turned in a column on ABYSS. It's a really interesting trial to translate to clinical care. There were also meta-messages about evidence-based medicine. Stay tuned #ESCCongress

Can we now get a sub analysis on astrological signs?

💯 👇🏻

It’s late in London but here’s my hot take of the ABYSS trial #ESCCongress — Okay to stop beta blockers after MI (good EF) medscape.com/viewarticle/be…

The non-inferiority bound was 10%. 😂 Anyone can parallel park in a space big enough to fit a school bus. A better question is: is there a single randomized trial that supports potassium supplementation for inpatients or outpatients?

I like my role at ⁦theheartorg | Medscape⁩ #esccongress

Dr Zipes used to say …Mandrola, a broken clock is right twice a day. I was right about this one. 👇🏻 Docs ought to be less enamored w plausibility medscape.com/viewarticle/ma…

“The higher rate CV hospitalization alone drove the results of ABYSS. Death, MI, and stroke rates were nearly identical.  The most common reason for admission to the hospital in this category was for angiography.” “ABYSS, therefore, is consistent with REDUCE-AMI.”

This hot take is the correct take. Clinicians, don't get stuck in your status quo by your loss aversion!

#ESCCongress Help needed. RESHAPE-HF2 is a hard one to sort out.

I just sent in my column on RESHAPE-HF. Teaser -- I've come to believe that functional MR is a super-diverse condition. It's hard to study--like AF and unlike STEMI. Average results from trials are hard to apply to individual pts. Please do tune in later #ESCCongress

I agree with notion that we don't know enough about LAAO. But that is totally "our" fault for accepting this therapy before having proper trials. If only a fraction of patients who have had this procedure were randomized, we WOULD know! #ESCCongress

It’s late in London again. Here’s my hot take of the third TEER trial in functional MR, REHAPE HF2 You’d think 3 trials in one space would sort out the answer. #ESCCongress medscape.com/viewarticle/te…

The first sham-controlled AF ablation trial has been done. Twenty years (and millions of procedures) after we started doing this procedure. The study has limitations but it is a big step forward. I need to take some time to sort it out. For now, though, our profession should

Beta-Blockers Post-MI? No for Me, Even After the ABYSS Trial medscape.com/viewarticle/be… via John Mandrola, MD

Which Presidential Candidate is More Anti-Science? Adam Cifu John Mandrola, MD sensible-med.com/p/which-us-pre…

One of the biggest and most ignored safety issues in hospital medicine: ECG computer reads. I’ve tried my entire career to have them removed so clinicians a) learn to read ECGs, and b) are not misled by wrong reads—like this one 👇🏻

Look up the definition of “elegant” It is a perfect word for this technique, which can replace $500 vascular closure devices. 👇🏻👇🏻 Problem is that stopcock makers don’t sponsor meetings or bring lunch or hire KOLs to speak. (Thx Piotr Futyma, MD for teaching me this trick)