Remarkable NEJM case report of a 58-year-old man with a speech-induced atrial heart rhythm disturbance, to rates <150 bpm, with breathlessness and dizziness, anytime he talked, fortunately relieved by a beta-blocker nejm.org/doi/full/10.10…

There’s someone in my life I love very much. He is a doctor. And, he is an alcoholic.

Do doctors understand how well treatments work? We asked >500 clinicians in 8 US states Chance that common treatments help an individual patient with atrial fibrillation hypertension high cholesterol osteoporosis Open access: ja.ma/3A1u7N4 via JAMA Network 1/🧵

In this European Society of Cardiology Journals sdy Casper Binding Anders Nissen Bonde et al found ♂️ sex and living alone 🛖 was associated w/ a 35.7%, (95%CI 37.3% to 34.1%) risk of #DOAC discontinuation among ptts w/ #Afib 📝bit.ly/2WdTPPV #CardioTwitter #cardiovascular #noac #research #dkforsk

HbA1c hits 48 mmol/mol, we send the cavalry – saving lives of people with #T2D, but overlooking #CVD risk reduction in #prediabetes(?) I think these data are thought-provoking and important for the management of prediabetes pubmed.ncbi.nlm.nih.gov/34675054/ HerlevGentofte Hosp. Steno Diabetes Center Copenhagen

REMINDER: A systematic review shows no performance benefit of #machinelearning over logistic regression for clinical prediction models (tinyurl.com/dnayhrms) -> "Improvements in methodology and reporting are needed" #keepitreal #dontbelievethehype #mlwtitter #statstwitter

Journal publication is a multi-billion industry… and this article estimates that academics donate at least $1.5b annually in labor to support the current enterprise. Write papers, donate reviews, often pay for publication. What a model. …rchintegrityjournal.biomedcentral.com/articles/10.11… HT Atul Butte

3.5 years after therapy with factor VIII-containing adeno-associated virus, 16 of 18 men with hemophilia A had enough factor VIII expression that bleeding events were reduced to nearly zero and prophylaxis was discontinued. nej.md/30vQDkL

Virkelig trist historie det her. Udokumenterede påstande om mRNA vaccinernes påvirkning af fertilitet har givetvis ikke hjulpet på gravides tiltro til dem. Vigtigt at slå fast: vaccinerne er sikker for gravide og kan beskytte det ufødte barn. ugeskriftet.dk/nyhed/fodselsl…

Interview i dagens medicin om vores nyeste studie, som viser at den farligste HbA1c-måling kan være den lige under 48. Behov for øget fokus på forebyggende behandling ved prædiabetes. dagensmedicin.dk/hoejere-risiko…

In a nationwide 🇩🇰 cohort sdy D Zahir et al found in ptts w/ #heartfailure 💔 half received MRA as 3️⃣-line therapy within the first 6️⃣ months after diagnosis and half of these withdrew MRA 💊 within 5️⃣ years 🔗bit.ly/3F2lSlS #cardiotwitter #Cardiology

I this JAHA sdy Naja Emborg Vinding et al found that in ptts w/ #ischemicstroke, ptts w/ #AFib 💗had more severe strokes 🤯 and ⬆️ mortality than ptts without AFib The difference ↔️ in mortality ☠️ was mainly driven by stroke severity 🔗bit.ly/3gLrQOu #CardioTwitter

What % of #EHR text is directly duplicated from a prior note? 6 yrs 100+ mil notes 33 B words 192 B characters Duplicated text ⬆️ from 33% in 2015 to 54% in 2020 Blocking copy forward is not the answer. We must reimagine #documentation jamanetwork.com/journals/jaman…

TTR'er med VKA var 57 % hos aleneboende ♂️ 59 % hos aleneboende ♀️ 63 % hos samboende ♂️ 61 % hos samboende ♀️ Antikoagulationskontrol er en følsom indikator på hvor godt man passer på sig selv Research letter af Anders Nissen Bonde i AmericanHeartJ sciencedirect.com/science/articl…

No matter what you were taught, don't bother to test for proportional hazards in survival analyses. Hazards are never proportional because hazard ratios vary over the follow-up if treatment has an effect on survival. Mats Julius Stensrud and I explain it here: jamanetwork.com/journals/jama/…

Efficacy and safety of #DOACs according to #renal function in #AF populations: data from >26K patients from Danish nationwide registers 🇩🇰 bit.ly/48GehrU Casper Binding Anders Nissen Bonde University of Copenhagen DoreenTan.CVPx Mattia Galli Felice Gragnano #AFib #CKD #EHJPharmacotherapy