Postdoc position available in the UCL POND group UCL CMIC developing machine learning tools to identify mixed pathology in dementia as part of my 8-year Wellcome-funded project. Closing date: 17th Dec. Please share: ucl.ac.uk/work-at-ucl/se…

Aksman et al. model the spread of AD pathologies, identifying amyloid-first and tau-first subtypes. Amyloid and tau may begin independently in spatially disconnected regions, with local amyloid–tau interaction triggering widespread neocortical tau. tinyurl.com/2s5563r5

Our lab identified novel subtypes of disease progression in TDP-43 confirmed #ALS and #FTD - highlighting a prefrontal/motor variant and limbic-predominant variant: rdcu.be/ds3QD Penn FTD Center Jake Vogel Jeff Phillips David Irwin Dr. Lauren Massimo PICSL

‼️New preprint‼️ 🔗Led by PhD student Sophie Mastenbroek, we unveil three different progression patterns of Lewy body pathology. Disease progression modeling of: * Postmortem Lewy-type α-synuclein data from 10 🧠 regions * N=814 donors 👇👇👇 biorxiv.org/content/10.110…

Probably the last pre-print from us for this year! We have investigated whether genetic risk in AD contributes differentially to transitions between different biomarker defined stages in the ATN framework. Spoiler: it does 👇👇👇 UCL CMIC DRC@UCL

New paper alert! rdcu.be/dvstu Our review paper on Data-Driven Disease Progression Modelling (D3PM) was published in Nature Rev Neurosci yesterday, co-led by myself, Alex Young, & Daniel Alexander at UCL Computer Science and UCL CMIC

📣Looking for hard-working interdisciplinary POSTDOC to take to next level multi-omics molecular-imaging modeling in neurodegeneration (AD, PD, ALS), at The Neuro. Please redistribute... See papers science.org/doi/10.1126/sc… and doi.org/10.1038/s41467…

Data-driven modelling of neurodegenerative disease progression: thinking outside the black box — a Review by Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Nick C. Fox, Frederik Barkhof, Jonathan M. Schott & Daniel C. Alexander go.nature.com/492x4yg

Happy to see our work published in Imaging Neuroscience EiC! We compare different types of brain network for modelling pathology spread in AD, and show how we can combine the different networks to improve our models 🧠 Code here: github.com/ethompson93/mu… UCL POND UCL CMIC

📢 Join us for the Basics of Artificial Intelligence in #Neuroimaging by David Jones, followed by panel discussion with Daniel Alexander, Christos Davatzikos, Alex Young 🗓️ March 1st, 10AM EST, 4PM CET ➡️Register here: alz-org.zoom.us/webinar/regist…

Are you an early-career scientist interested in learning about the latest advances in medical image computing? The 10th UCL Medical Image Computing Summer School (MedICSS 2024) will take place from 1st – 5th July 2024 in person in Central London. ucl.ac.uk/medical-image-…

‼️ Postdoc ad // Please RT/circulate ‼️ Are you interested in * Big euroimaging and multi-omic data? * Neurodegenerativ disease? The BioFINDER is looking for a talented postdoc to sink their teeth into some rare and exciting data! Apply here: lu.varbi.com/en/what:job/jo…

Extremely happy to see this one out at last!!!🎉🎊 Here, we showed that a single CSF draw 💉is sufficient to accurately stage participants along the #Alzheimer's continuum. This has been a long and tough journey, but totally worth it to finally share it with the whole community☺️

The first EU-MIND Congress takes place on 25-27 September in Caen, Normandy. The deadline for submitting your neuroimaging abstracts and travel awards is today. Be sure to submit! eu-mind.org/abstracts-subm…

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology Sophie Mastenbroek strikes again! Using SuStaIn modeling of neuropathological data (n=814) we show substantial heterogeneity in the temporal spread of Lewy body pathology, with

I am hiring a research technician to help process and analyze multimodal neuroimaging data. Please RT!! * Great opportunity to gain research experience pre-PhD * Access to exciting data * Opportunities for independent projects Apply here: lu.varbi.com/en/what:job/jo…

I'll be talking about multi-modal connectomes for modelling tau spread on Wednesday morning (4-2-FRS-D) and showcasing our group's network spreading model toolbox tomorrow at the AIC and in the poster session on Monday (Monday-475, AIC-340) 🧠🧠🧠 github.com/ucl-pond/netwo…

For more network-spreading goodness, check out Sonja Soskic's poster (Monday-910), where she uses the toolbox to model the impact of neurotransmitter receptors on amyloid and tau accumulation ✨ UCL POND UCL CMIC

Estarellas et al. report that an adapted Subtype and Stage Inference algorithm accommodates missing data in multimodal #Alzheimersdisease studies. Mar Estarellas MIG POND UCL Neil Oxtoby (Toybox Science) Jonathan Schott Daniel Alexander Alex Young edin.ac/3SjesUI