Very excited to share our latest publication investigating the neuropathological staging of #PSP. Special congratulations to former Spillantini lab member and first author Mayen, who also passed her PhD last week 🎉 sanne kaalund Cambridge FTD Cambridge Brain Bank

Now on bioRxiv: 35+ #Tau structures from 6 cases of #PSP, 2 #GGT, 2 #AGD, 1 #ARTAG, 3 #intron10mutants, 1 #FBD and 1 #FDD allow structure-based classification of #tauopathies and the identification of a new disease (#LNT with GPT filaments). biorxiv.org/content/10.110…

Amazing to see such a comprehensive study of the #PSP tau structure

Now out on bioRxiv: #cryoEM structures of #amyloidBeta42 filaments from #Alzheimers and other diseases. By the wonderful Yang Yang, Diana Arseni & wenjuanzhang et al, together with B. Ghetti, Benjamin Ryskeldi-Falcon & Michel Goedert. 🥳 biorxiv.org/content/10.110…

🔔New paper alert 🔔Excited to share our latest microglia paper by Jack Brelstaff et al. "Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates" science.org/doi/10.1126/sc…

On #InternationalWomensDay we celebrate all our female staff and alumni. #LMBAlumni Maria Grazia Spillantini recently shared her memories of when she began her research into #tau & #synuclein proteins in the LMB’s Director’s Division: www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-… #WomensDay #IWD2022

Excited to attend #ADPD2022 this week! Prof. Spillantini presented on interactions of neurons and glial cells in neurodegenerative diseases yesterday. Come visit us at our posters from PhD students Janine Brandes and Helen Dakin (boards 300 and 5).

Very happy to have contributed to this collaborative paper with Sjors Scheres and Michel Goedert labs! Congratulations to all the authors, including our Mehtap Bacioglu👏

After quite a while, we've finally managed to crack the #cryoEM structure of #alphasynuclein filaments from #Parkinsonsdisease and #DLB, which share a common fold, suggesting these diseases are on a continuous spectrum. 🥳🥳🥳 As always with Michel Goedert. biorxiv.org/content/10.110…

We have an open position for a Research Associate to work on an exciting new project on "Single Cell Analysis and Mitochondrial Ageing". Please find out more here: jobs.cam.ac.uk/job/37394/ and apply by 26th October.

We're excited to announce that our new paper on the use of RT-QuIC to detect alpha-synuclein in saliva in PD has been published. Congratulations Giorgio Vivacqua! …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

We are looking for a postdoc to join our team to work on mitochondrial DNA mutations. Find out more here jobs.cam.ac.uk/job/38753/ and apply by 27th of January.

We are recruiting! Two postdoc positions are available in our lab to work on mitochondrial DNA in PD or spreading of alpha-synuclein from the gut. Find out more here: jobs.cam.ac.uk/job/38753/ and here: jobs.cam.ac.uk/job/40057/

We were excited that Professor Spillantini co-chaired and gave a talk during an all female session at the #ADPD2023 today! #WomenInScience

We have an open postdoc position as part of the ASAP team to work on understanding the spread of alpha-synuclein. Apply until the 16th of August here: jobs.cam.ac.uk/job/42199/

Are you interested in mitochondria and Parkinson's disease? We have an open 3 year postdoc position! Find more info and apply until the 29th of August here: jobs.cam.ac.uk/job/38753/

What a great time with SpillantiniLab and Coleman Lab at Cambridge! Maria told us the story of how she found alpha-synuclein to be a key component of Lewy bodies (1st pic in front of microscope room where she made the discovery).

It’s Day 3 of exciting new science at #ADPD2024! Prof. Spillantini gave a talk yesterday on our new mouse models expressing synuclein in gut and nasal epithelium. Come check out poster 0483 by our PhD student Pauline Vessiere on the effect of LRRK2 inhibition in these models.

We are thrilled to announce that Professor Spillantini has been elected as a member of EMBO! 👏 cam.ac.uk/stories/EMBO-2…