#CryoEM structures of tau filaments of individuals with P301T or P301L mutations reveal novel folds, suggesting that models with such mutations should be used with caution in the study of sporadic tauopathies, such as #Alzheimers. With Michel Goedert. biorxiv.org/content/10.110…

FTDP-17 mutations P301L and P301T in MAPT give rise to novel tau filament folds. Individuals with mutations of P301 have distinct tauopathies. Great work: Manuel Schweighauser, Yang Shi, Alexey Murzin. As always with Sjors Scheres. biorxiv.org/content/10.110…

Cool stuff! 😍

Just left my full support for the bridge closure in the consultation. Mill Road is a dangerous road for cyclists and pedestrians (the latter need to step onto the road because many cars park on the pavement). It is time Mill Road became less car-focused. 😃

Does anyone have a robust program that computes an MRC map from a PDB file, such that the generated map superimposes on the corresponding EMDB map, without the need for further alignment? I thought this was easy...

🛠️New Method available An image processing pipeline for electron cryo-tomography in RELION-5 🔓buff.ly/4dRmNHz 🥼Alister Burt Bogdan Toader Tanmay Bharat Sjors Scheres #OpenSoftware #CryoET #StructuralBiology #ElectronTomography #Microscopy

Hey, fitbit Fitbit Support , is it to be expected that the battery on my 2 year old Charge 5 has died, after several days of draining quickly and overheating when charging? Isn't that disappointing?

Great to see that Kiarash Jamali's #ModelAngelo was so useful in identifying this new virus through #cryoEM structure! 😍

Wow, that is amazing! 😍