Our recent paper on Am J Epidemiology ➡️ Estimating and presenting hazard ratios and absolute risks from a Cox model with complex nonlinear interactions academic.oup.com/aje/article-ab… TIMI Study Group Giorgio Melloni

I’m honored to work with such an amazing team on this clinically meaningful project. Plus, huge thanks to WIN ADA for the abstract award! Stephen Wiviott Nicholas Marston Giorgio Melloni Filipe A Moura, MD, PhD TIMI Study Group Brigham and Women’s Endocrinology American Diabetes Association - DiabetesPro

Congrats Yumi! Very well deserved!!

Now in JAMA Cardiology: 👴 ≥80 yrs with AFib 💊 *No* dose-reduction criteria 🎲 Lower-dose (vs. full-dose) ATC with edoxaban 👉 In elderly pts with AF, an "off-label" lower-dose anticoagulant led to fewer major bleeds & no increase in ischemic events. TIMI Study Group Robert Giugliano

Have you ever considered genetic testing in pts with early-onset AF (<45 years) as an EP? Probably not, maybe you should. In our recent state-of-the-art review EHJ Editor-in-Chief we discuss implementation of genetic testing in AF clincial care. #EPeeps #CardioTwitter. A thread🧵

Should all elderly pts get low-dose DOAC? Randomized analysis supported by PK/PD data from ENGAGE AF-TIMI with #edoxaban 60 vs 30 in elderly says 30 mg dose as effective with far less GI bleeding André Zimerman Robert Giugliano jamanetwork.com/journals/jamac…

Our CHIP analysis of 64K individuals across 5 TIMI Study Group CVOTs is now published in Nature Medicine.. We looked at the association between CHIP and MACE in pts w/ and w/o prior events and the treatment effect with PCSK9i, SGLT2i, P2Y12i, & Factor Xai Thread and link below..

Rare cardiomyopathy-associated genetic variants are associated w/outcomes in AF pts. AF pts w/rare variants have more HF at dx, more HF-related hospital admissions & more cardiovascular death during follow-up. Genetic testing might affect prognosis. Nicholas Marston #ESCCongress

Check out our just presented Late-breaking science on a machine learning algorithm using POCT and immediately available clinical variables for immediate rule-out of myocardial infarction:

TIMI is proud to celebrate our 40th anniversary! Since 1984, we've been dedicated to advancing the knowledge and care of patients suffering from cardiovascular disease and its risk factors. View the 40th anniversary edition of the TIMI book, now online. timi.org/40th-anniversa…

Deep dive into the relevance of frailty in ACS in a large dataset from Germany - presented by Johannes Neumann in the Late-breaking science session at the ESC Congress 👏🏻

Dr. @sidpatelmd delivers his late-breaking presentation on long-acting factor XI inhibition and periprocedural bleeding in AZALEA-TIMI 71, tomorrow at 15:15 in Cairo #ESCCongress

How often have you seen pts w/ AF-related systemic embolism in clinical routine? or was stroke you’re main concern? Elegant analysis by Samer Alsaid and Robert Giugliano presented at #ESCCongress using data of the 4 pivotal #DOAC RCTs forming the COMBINE-AF individual pt database

More bang for your buck with #PCSK9i evolocumab in pts w/ obesity! Fantastic presentation of Yumi Kang, MD, PhD at #ESCCongress TIMI Study Group Robert Giugliano Michelle O'Donoghue

In the COMBINE-AF study, #biomarkers NTproBNP, hs-cTnT & GDF-15 improve #heartfailure risk assessment in #Afib! hs-cTnT is equally important as #NTproBNP for HF risk assessment bit.ly/3ySKhNR #ESCCongress #JACC Paul M Haller Robert Giugliano TIMI Study Group

Using exome seq in 63,700 pts from 5 TIMI CV outcome trials, we observed 866(1.3%) CMP variant carriers. These pts had ↑ rates of hospitalization for HF, incident AF & DCM variant carriers in particular of CV death over ~2.5 years of f/u. Nicholas Marston Shino Kany #ESCCongress

Does elevated LDL cause aortic stenosis? 🥓🫀🩺 Excited to share our study linking rare LDL-associated genetic variants to aortic stenosis 🧬 Published in @Circulation and presented at #ESCCongress2024 today Broad Institute UCSF Health Link: ahajournals.org/doi/10.1161/CI…

Extracranial systemic embolic events (SEE) in AF are less frequent than ischemic stroke but just as fatal. Our IPD analysis of 71,683 AF pts from the pivotal DOAC vs. warfarin RCTs showed that DOACs are superior to warfarin in preventing SEE #ESCCongress2024

Check our paper in nature nature.com/articles/s4158… This is a huge collaborative work combining great basic and clinical science, with important implications for the prevention of atherosclerotic cardiovascular disease. Thanks to all our collaborators and funders!

Recognition of preshock or early CS states is important to facilitate early identification, to guide appropriate triage and to enable prompt interventions aimed at delaying or preventing the onset of overt CS. bit.ly/3zeRsQn #JACCHF Sid M. Patel TIMI Study Group