Aatur Singhi, MD PhD (@pancpathologist) 's Twitter Profile
Aatur Singhi, MD PhD

@pancpathologist

Pancreatic/Gastrointestinal Pathologist.
T/RT ≠ medical advice

ID: 720433802791776256

calendar_today14-04-2016 02:09:38

4,4K Tweet

7,7K Followers

4,4K Following

Aatur Singhi, MD PhD (@pancpathologist) 's Twitter Profile Photo

Pancreatic neuroendocrine tumor (PanNET), WHO grade 1, 2.3 cm, ATRX mutant (& alternative lengthening of telomeres [ALT]). ALT-pos. NETs often have venous invasion (w/ tumor thrombi), leading to metastases #Pancreas #NET #PancreaticCancer #NeuroendocrineTumor #GIPath #Pathology

Pancreatic neuroendocrine tumor (PanNET), WHO grade 1, 2.3 cm, ATRX mutant (& alternative lengthening of telomeres [ALT]). ALT-pos. NETs often have venous invasion (w/ tumor thrombi), leading to metastases #Pancreas #NET #PancreaticCancer #NeuroendocrineTumor #GIPath #Pathology
Katie Galloway (@gallowaylabmit) 's Twitter Profile Photo

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n)
Link: doi.org/10.1101/2024.0…
Aatur Singhi, MD PhD (@pancpathologist) 's Twitter Profile Photo

Pancreatic Adenosquamous Carcinoma (#PASC) is an aggressive variant of pancreatic ductal adenocarcinoma (#PDAC), characterized by glandular and squamous differentiation (at least 30% of the neoplasm) & can harbor BRCA/PALB2 mutation. #GIPath #Pathology #PancreaticCancer #Pancreas

Pancreatic Adenosquamous Carcinoma (#PASC) is an aggressive variant of pancreatic ductal adenocarcinoma (#PDAC), characterized by glandular and squamous differentiation (at least 30% of the neoplasm) & can harbor BRCA/PALB2 mutation. #GIPath #Pathology #PancreaticCancer #Pancreas
Anirban Maitra (@aiims1742) 's Twitter Profile Photo

New preprint from Prof David K. Chang Nigel B. Jamieson & colleagues Clonal evolutionary analysis reveals patterns of malignant transformation in #PancreaticCancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN) biorxiv.org/content/10.110… Phylogenetic analysis identifies two distinct

New preprint from <a href="/dkfchang/">Prof David K. Chang</a> <a href="/nigeljamieson/">Nigel B. Jamieson</a> &amp; colleagues 
Clonal evolutionary analysis reveals patterns of malignant transformation in #PancreaticCancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN)
biorxiv.org/content/10.110…
Phylogenetic analysis identifies two distinct
Anirban Maitra (@aiims1742) 's Twitter Profile Photo

New preprint from Chris Iacobuzio MSKCC Center for Pancreatic Cancer Research Genomic evolution of #PancreaticCancer at single-cell resolution biorxiv.org/content/10.110… Eileen M O’Reilly Wungki Park, MD MS Ben Raphael This study sequenced 137,491 single-nucleus DNA libraries from 24 pancreatic cancers, including primary

New preprint from <a href="/ciacobu/">Chris Iacobuzio</a> <a href="/CpcrMsk/">MSKCC Center for Pancreatic Cancer Research</a> 
Genomic evolution of #PancreaticCancer at single-cell resolution
biorxiv.org/content/10.110…
<a href="/EileenMOReilly/">Eileen M O’Reilly</a> <a href="/CentralParkWMD/">Wungki Park, MD MS</a> <a href="/benjraphael/">Ben Raphael</a> 
This study sequenced 137,491 single-nucleus DNA libraries from 24 pancreatic cancers, including primary
Anirban Maitra (@aiims1742) 's Twitter Profile Photo

From Luciane T Kagohara 🇧🇷🧬👩🏻‍🔬👩🏻‍💻 Ashley Kiemen Denis Wirtz & colleagues Johns Hopkins Kimmel Cancer Center PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration sciencedirect.com/science/articl… Spatial transcriptomics of archival #PancreaticCancer precursor lesions, with validation

From <a href="/ltkagohara/">Luciane T Kagohara 🇧🇷🧬👩🏻‍🔬👩🏻‍💻</a> <a href="/AshleyKiemen/">Ashley Kiemen</a> <a href="/deniswirtz/">Denis Wirtz</a> &amp; colleagues <a href="/hopkinskimmel/">Johns Hopkins Kimmel Cancer Center</a> 
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
sciencedirect.com/science/articl…
Spatial transcriptomics of archival #PancreaticCancer precursor lesions, with validation
Aatur Singhi, MD PhD (@pancpathologist) 's Twitter Profile Photo

Intraductal Oncocytic Papillary Neoplasm (IOPN), #HGD, of the main & branch ducts in the #Pancreas. Interesting story, FNA in 2010 when 1.8 cm & repeat testing found a PRKACA fusion. The patient was asked to f/u & now 6.0 cm. #Pathology #GIPath #PancreaticCancer #PancreaticCyst

Intraductal Oncocytic Papillary Neoplasm (IOPN), #HGD, of the main &amp; branch ducts in the #Pancreas. Interesting story, FNA in 2010 when 1.8 cm &amp; repeat testing found a PRKACA fusion. The patient was asked to f/u &amp; now 6.0 cm. #Pathology #GIPath #PancreaticCancer #PancreaticCyst
Itai Yanai (@itaiyanai) 's Twitter Profile Photo

Every project is unique – like a ❄️– but after experiencing many projects it also gets pretty clear that there is pretty much a common way they unfold, once the initial idea happens:

Every project is unique – like a ❄️– but after experiencing many projects it also gets pretty clear that there is pretty much a common way they unfold, once the initial idea happens:
Noor Shaker (نور) (@noorshak) 's Twitter Profile Photo

Super excited to share early results from our collaboration with Aatur Singhi, MD PhD, MD, at UPMC. We are using unsupervised machine learning to classify shark core biopsy of the pancreas, extracting data-driven features essential for classification without any human input.

White House Office of Science & Technology Policy (@whostp) 's Twitter Profile Photo

Solid tumors make up about 90% of cancer cases. The Biden-Harris Administration announced $150M from ARPA-H to develop technologies that provide more successful tumor-removal surgeries to help meet the Biden Cancer Moonshot’s goal of saving lives. whitehouse.gov/briefing-room/…

Pitt Division of GI, Hepatology & Nutrition (@pittgilivernutr) 's Twitter Profile Photo

👏👏👏 Congratulations to Dr. Dhiraj Yadav & Dr. Yogish Kudwa on a new R01 - a clinical trial evaluating Pioglitazone for treatment of #diabetes in patients with #pancreatitis.

👏👏👏 Congratulations to Dr. Dhiraj Yadav &amp; Dr. Yogish Kudwa on a new R01 - a clinical trial evaluating Pioglitazone for treatment of #diabetes in patients with #pancreatitis.
Jennifer Guerriero, PhD (@jennguerriero) 's Twitter Profile Photo

Padmanee (Pam) Sharma, MD, PhD kicking off the #Tumorimmunology session Cold Spring Harbor Laboratory #cshlcancer24 meeting with a brilliant talk on identifying mechanisms of resistance to reveal novel targets for immune checkpoint combination.

<a href="/PamSharmaMDPhD/">Padmanee (Pam) Sharma, MD, PhD</a> kicking off the #Tumorimmunology session <a href="/CSHL/">Cold Spring Harbor Laboratory</a> #cshlcancer24 meeting with a brilliant talk on identifying mechanisms of resistance to reveal novel targets for immune checkpoint combination.
UPMC (@upmcnews) 's Twitter Profile Photo

Researchers from UPMC & Pitt Health Sciences are testing the use of #mRNA to get damaged livers to repair themselves, in a move that could one day lessen the need for organ transplants. Check out the full story from WIRED 👇 wired.com/story/mrna-org…

Gianrico Farrugia (@gfarrugiamd) 's Twitter Profile Photo

Mayo Clinic’s fully automated AI-enabled pathology slide digitization operation, the largest in the world, is reinventing the practice of pathology by scanning 36,000 slides a day and converting these assets to a multimodal platform of data: mayocl.in/4dzL2KT

UPMC Pathology Residency Program (@upmcpath) 's Twitter Profile Photo

The First UPMC Pathology Residency Program Virtual Open House will be held Wednesday, August 28, from 6:00P - 7:30P (EDT). Link to UPMC Pathology Residency website: path.pitt.edu/training/clini……SurveyMonkey Virtual Open House Sign-Up link: surveymonkey.com/r/UPMC_Patholo…

The First UPMC Pathology Residency Program Virtual Open House will be held Wednesday, August 28, from 6:00P - 7:30P (EDT). Link to UPMC Pathology Residency website: path.pitt.edu/training/clini……SurveyMonkey Virtual Open House Sign-Up link: surveymonkey.com/r/UPMC_Patholo…
Hao Yin (@haoyin20) 's Twitter Profile Photo

SRplot: A free online platform for data visualization and graphing bioinformatics.com.cn/login_en/ Happy to see a citable paper published for this very handy website (Learned a lot of data & graph formats here😁) Yewei Wang lab PLOS ONE 2023 journals.plos.org/plosone/articl…

SRplot: A free online platform for data visualization and graphing

bioinformatics.com.cn/login_en/

Happy to see a citable paper published for this very handy website (Learned a lot of data &amp; graph formats here😁)

Yewei Wang lab <a href="/PLOSONE/">PLOS ONE</a> 2023
journals.plos.org/plosone/articl…
UPMC Pathology Residency Program (@upmcpath) 's Twitter Profile Photo

The Second UPMC Pathology Residency Program Virtual Open House will be held Thursday, September 12, from 12:00P - 1:30P (EDT). Link to UPMC Pathology Residency website: path.pitt.edu/training/clini… SurveyMonkey Virtual Open House Sign-Up link: surveymonkey.com/r/UPMC_Patholo…

The Second UPMC Pathology Residency Program Virtual Open House will be held Thursday, September 12, from 12:00P - 1:30P (EDT).
Link to UPMC Pathology Residency website: 
path.pitt.edu/training/clini…
SurveyMonkey Virtual Open House Sign-Up link: surveymonkey.com/r/UPMC_Patholo…
Linghua Wang, MD, PhD (@iamlinghua) 's Twitter Profile Photo

1/ A simple yet effective tool that integrates tissue #histology, cell morphology, and #SpatialTranscriptomics for profiling tumor and immune cell states, co-localization, and interactions within tissues nature.com/articles/s4146…