State of the art molecular immunology in an idyllic Tuscan landscape! Applications are open for the Lymphocyte Antigen Receptor Signalling Workshop at the Certosa di Pontignano 1-5 June 2024. ndorms.ox.ac.uk/events/lymphoc…

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development biorxiv.org/content/10.110…

New #JITC article: CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation bit.ly/3uHFfBM Jiri Eitler

New study reveals how T cells gain and maintain tolerance to gut bacteria kennedy.ox.ac.uk/news/new-study…

Dr Ashwin Jainarayanan selected for 2024 Schmidt Science Fellow program | University of Oxford ox.ac.uk/news/2024-05-0…

RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1 biorxiv.org/content/10.110…

CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics biorxiv.org/content/10.110…

Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses biorxiv.org/content/10.110…

The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…

Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells: Cell Reports cell.com/cell-reports/f…

Excited that this heroic study on nuclear positioning of PD-1 locus in primary T cells from acute and chronic viral infection models is out!

Excited that we got the cover on a special issue of Biophysical Journal on Biophysics of Immune Cell Signaling with Jesusa Capera NDORMS Kennedy Institute of Rheumatology article on Dynamics and spatial organization of Kv1.3 at the immunological synapse... sciencedirect.com/science/articl…

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells biorxiv.org/content/10.110…

🚨 New preprint alert! 🚨 Our latest research on #Cytokines and #Tcells reveals a synergistic regulation between the IL2 receptor and the TCR that is dependent on their spatiotemporal proximity at the immunological synapse. Check it out! #Immunology Michael Dustin Cue Biopharma

2/ 🚀Fascinating breakthrough! IL2 receptor subunits are released via #ExtracellularVesicles, sparking #IL2 #signaling in other #Tcells. Implications for #Cytokines and #Immunotherapy are huge! 💥Excited to share this with Ashwin Jainarayanan Michael Dustin Cue Biopharma

4/🧬Driving Precision Immunotherapy Forward!🧬We use #ImmunoSTATs, which fuse #IL2 and pMHC molecules, creating a powerful tool to selectively expand antigen-specific #Tcells. Paving the way for more targeted immune responses! #Immunotherapy Michael Dustin Cue Biopharma

Immuno-STATS create an immunological synapse to boost both the T cell receptor and IL-2 receptor signaling among the RIGHT T-cells!

Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out Nature Immunology nature.com/articles/s4159… 🥳🎉🍾. A 🧵:

Just a couple of days left to apply to join my lab

Reaching last day of an amazing event including three new The Royal Society Medal recipients!