An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo pnas.org/content/116/24… PNASNews MGH Center for Systems Biology Mass General Imaging Institute for Innovation in Imaging Mass General Research Institute MGHNeuroRadFellows

A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales thno.org/v09p7525.htm #Theranostics Theranostics Institute for Innovation in Imaging MGH Center for Systems Biology Mass General Imaging Mass General Research Institute MGHNeuroRadFellows

Happy Holidays!

Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know ajnr.org/content/early/… @AJNR MGH Center for Systems Biology Institute for Innovation in Imaging

A more powerful molecular MRI agent (4-10X higher than conventional MRI agents) to report on myeloperoxidase activity, which reflects oxidative stress and damaging inflammation. doi.org/10.1021/acs.jm…. Mass General Imaging MGH Center for Systems Biology MGHNeuroRadFellows Harvard Medical School Mass General Research Institute JMedChem

Does gadolinium deposition in the brain have clinical consequence? Lessons from animal studies. doi.org/10.1148/radiol… Radiology Mass General Imaging MGH Center for Systems Biology Institute for Innovation in Imaging Mass General Research Institute MGHNeuroRadFellows

In this editorial, Dr. Chen discusses results from the article by Akai et al. on mouse model investigation of gadolinium brain deposition and behavioral testing, as well as the safety and medicolegal impact of these results. bit.ly/3gPgGss MGH JWChen Lab @HarvardMed

Great symposium on translational imaging of inflammation coming up at the end of October. Hope to see you there! i3.mgh.harvard.edu/inflammation/ i3 Imaging Symposium MGH Center for Systems Biology Mass General Imaging MGH Martinos Center Mass General Research Institute MGHNeuroRadFellows James Brink, MD Matthias Nahrendorf stands with Israel Fil Swirski & Scientists MGH Radiology Chiefs UCSF Imaging

D-mannose, a commonly available dietary supplement and a simple sugar, can improve neuroinflammation by suppressing oxidative stress and blocking phagocytosis. doi.org/10.1073/pnas.2… PNASNews MGH Center for Systems Biology James Brink, MD MGH Radiology Chiefs Mass General Research Institute MGHNeuroRadFellows Institute for Innovation in Imaging Caravan Lab

Myeloperoxidase, a highly oxidizing enzyme, exerts anti-tumor activity in glioma after radiotherapy. This could help optimize host immune response and therapy for this devastating disease. sciencedirect.com/science/articl… MGH Center for Systems Biology James Brink, MD MGH Radiology Chiefs Mass General Research Institute MGHNeuroRadFellows Institute for Innovation in Imaging