Snake venom botrocetin facilitates VWF binding 3 to platelet GPIbα Shen et al show Botrocetin induce aggregation in GPIbα deficient platelets BUT inhibit fibrinogen binding/thrombus formation in absence of VWF, New antithrombotic⁉️ renhao li University of Toronto jthjournal.org/article/S1538-…

Gaspar et al USP - Universidade de São Paulo show Endothelial peri/epicellula disulphide isomerase (PDI) regulates platelet-endothelium interaction in hyperglycemia through adhesion-related proteins and alterations in endothelial membrane biophysics. jthjournal.org/article/S1538-…

Feasibility of a subcutaneous FIX therapy demonstrated in a preclinical model. Schön et al demonstrate efficacy of albumin fused recombinant Padua Factor IX, with enhanced activity, following subcutaneous administration in #Hemophilia B mouse model. jthjournal.org/article/S1538-…

Bleeding phenotype according to factor level in 825 children with non-severe #hemophilia - data from the PedNet cohort. pednet.eu jthjournal.org/article/S1538-…

Thank you JTH for publishing this important work by Dr. Maria T DeSancho and ATHN!

5/ Scramm in JTH show that along with significantly delayed clot formation, ITP patients had increased clot density and impaired fibrinolysis. Also high PAI-1 and low tPA levels. Possible mechanism for increased risk of thrombosis in ITP. tinyurl.com/272hnemp🔒

#ECMO aggravates platelet GPV shedding & δ-granule deficiency in #ARDS. ▶️New mechanisms mediating bleeding in critically ill pts ⁉️ Schulze-lab Lukas Weiss, NieswandtLab Kristina Mott SFB1525 Cardio-Immune Interfaces DIVI e.V. ESICM Universitätsklinikum Würzburg #WuerzburgPlateletGroup jthjournal.org/article/S1538-…

Join us right now at Science Box 4 #ESCCongress as Simon Kraler present our results on CV risk stratification in patients with cancer. A great collaboration Università di Genova Center for Molecular Cardiology MedUni Wien Florian Moik Federico Carbone Davide Ramoni Cihan Ay Florian Wenzl CardioTomLuscher

Check out our #ESCCongress 2024 simultaneous #CardioOncology publication on a novel risk score for MACE in cancer patients - now online JTH jthjournal.org/article/S1538-… Lucky me to have such a great team! Many thanks to Luca Liberale Cihan Ay Florian Moik CardioTomLuscher

Lack of #FVIII detection in humans/dogs with an intron-22 inversion challenges hypothesis regarding inhibitor risk It argues against promotion of immune tolerance through expression of partial FVIII proteins in intron-22 inversion patients JTH⁩ jthjournal.org/article/S1538-…

Interesting study assessed a broad panel of #cardiovascular biomarkers and risk factors for the prediction of major adverse cardiovascular events and cardiovascular death in 2192 #cancer patients. jthjournal.org/article/S1538-… JTH

It is #September and we're happy to show new #coverart Neutrophils, most abundant white blood cells ▶️ pivotal roles in innate immunity. Zukas et al @vollitionamerica describe novel, high-throughput ex vivo whole blood–induced NETosis model. jthjournal.org/action/showPdf…

Another study on AVWS during extracorporeal membrane oxygenation support (ECMO). Results suggested that almost all ECMO patients develop partial or complete loss of #VWF HMWM within a few hours after device implantation JTH⁩ jthjournal.org/article/S1538-…

Selected #September by EIC Aging is independent risk for #cardiovascular disease. Irina Portier show mTOR phosphorylation 🔼 Rac1 and p38 activation 🔼TxA2, #platelets hyperactivity & thrombosis. Robert Campbell jthjournal.org/article/S1538-… #OpenAccess

INR targets are widespread in guidelines. Incidentally abnormal INR in non-bleeding pts ▶️ plasma transfusion. INR targets as 1.7 are likely echoes of PT ratio ranges from pre-INR standardization era. Dr. Rita Selby @jeanniecallum @razasn jthjournal.org/article/S1538-…

A very informative article, specially in understanding the applicability of INR and avoiding unnecessary anxiety if clinically irrelevant.

Please join us in giving a HUGE thank you to Dr Dianne E. van der Wal 💉🔬👩‍🎓 her/hers for serving as a JTH social media editor for over five years🎊🎇, we will surely miss you Dianne!! We are also thrilled to give a warm welcome to Thita Joy Chiasakul as our new social media editor for X.