New Paper Alert. Ella Nicklin leads our new paper in Developmental Biology Evolution, development, and regeneration of tooth-like epithelial appendages in sharks. What do all 'odontodes' have in common? Is a tooth, just a tooth? #sharks #teeth #skinteeth sciencedirect.com/science/articl…

Did you know that the agricultural revolution shaped human genomes? This is a wonderful biological story and here you can read about research showing how starch-rich diets in human populations had a major role in the evolution of amylase genes, that facilitate starch digestion.

We have a new preprint out on @bioRxivpreprint! Check how we developed a new presynapse-on-glass model based on micropatterns to reveal the functional nano-architecture of presynapses: doi.org/10.1101/2024.0… (1/7)

Last year, we published a study using bead-induced isolated presynapses to visualize presynaptic actin down to the nanoscale. With STORM, we discovered distinct actin nanostructures within the presynapse: actin corrals, mesh and rails: doi.org/10.1083/jcb.20… (2/7)

So we developed a model of presynapses induced by small dots (1.8 µm-diameter) of recombinant Fc-neuroligin micropatterned on a regular polylysine-coated coverslip thanks to @ManuelThery's help. Presynapses form along isolated axons on or near the dots (4/7)

Dot-induced presynapses recapitulate the presence of actin-enrichment found in bead-induced presynapses. We could perform multicolor, 3D STORM-PAINT imaging of presynaptic actin together with bassoon, refining the localization of the corral, mesh and rails using 3D renders (5/7)

Finally, dot-induced presynapses are a great model for correlative imaging of presynaptic exocytosis and nanostructure. Their reliable orientation toward the glass allowed to correlate sub-diffraction exocytic sites to the nanoscale organization of Munc13, bassoon and actin (6/7)

Great work from PhD student Sofia Tumminia and postdoc Louisa Mezache, with key involvement of MJ Papandréou and help from terrymosoly, @ManuelThery and B Vianay, funded by @FRM_Officiel. Hope you'll like it and that it will find a good home soon! biorxiv.org/content/10.110… (7/7)

Are you a cerebrovascular lover? 🧠 Do you want help uncover when&why the neurovascular coupling starts during the neonatal period? I have a position that will suit you. Please RT #neonatalbrain #neurovascularcoupling #vascularbiology Apply here 👇 lnkd.in/da6tj3dC

Wonderful opportunity with a great PI! 👇👇👇

Preprint alert #AortaEd A mouse model with FBN1 G234D variant😎 👉Spontaneous lethal Thoracic #AorticAneurysm #AorticDissection (Abdominal aorta not so impacted) 👉Intimomedial tears (synchrotron tomography) Homozygotes 1 wk of age 👉Microscopic elastin breaks (any early

#DBfeature #SeaUrchin 🌊 Localization and origins of juvenile skeletogenic cells in the sea urchin Lytechinus pictus by Heidi M. Tate, Deirdre Lyons et al Heidi Tate Deirdre Lyons sciencedirect.com/science/articl…

#NAVBO2024 NAVBO Elizabeth Jones navbo.org/vb2024/

Still time to Register for NAVBO's DEI event! Tuesday Sep 10 at 1pm EST. Women in Science: Challenges and Coping Strategies (Part 2): Mentorship Details and link: rb.gy/1837cw

A living transparent mouse has been a dream of many. Exciting steps have now been achieved, as reported in Science. See my and other experts' comments on this new study here: Science: science.org/content/articl… STAT: statnews.com/2024/09/05/tis… ZEIT: zeit.de/wissen/2024-09… Study:

Faculty search in neuroscience (broadly defined) in Biology dept at Stanford! Come and be my colleague! We are interested in ALL areas of neuroscience including structural, molecular, cellular, developmental, systems-level, computational, and technology development.

👋 The Western Canadian Neuromuscular Conference can now be found across all social media channels! Follow their accounts to stay informed on conference updates and other important information. ⏰The #WCNMC is accepting abstract submissions until Sep 13th. Submit yours at: wcnmc.ca/en/

Check out these nice orange presynapses lining up on the little gray neuroligin dots! 🟠⚪️🟠⚪️

#AortaOnAChip Aortic #SmoothMuscleCell grown in a 3-layered PDMS #Microfluidics +#CyclicStrech reveal Notch1 deficiency-induced #MitochondrialDysfunction in #BicuspidAorticValve #AorticAneurysm Vacuum-induced rhythmic strain😎 eLife - the journal 2021 elifesciences.org/articles/69310